Archive | April, 2013

Facebook building $1.5 billion data center in Altoona, Iowa

23 Apr

DNP  Facebook building $15 billion data center in Altoona, Iowa

Facebook has already set up shop in North Carolina and Oregon, but it’s heading to Iowa for its next — and biggest — data center. According to the Des Moines Register, the town of Altoona will be home to a 1.4-million-square-foot facility (code-named Catapult), and it will reportedly be the “most technologically advanced center in the world.” Why Altoona, you ask? The city is already home to several data hubs, as its fiber-optic cable system, access to power and water utilities and affordable land are big draws for companies. Facebook will complete project Catapult in two $500 million phases, though the entire cost will reportedly ring in at $1.5 billion. The social network is also seeking wind energy production tax credits, which is no doubt connected to its Open Compute Project for promoting energy efficiency. That’s all we know so far; suffice to say a center this big won’t be built overnight.

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Via: TechCrunch

Source: Des Moines Register


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Simplee Combines And Paypal To Bring Medical Bill Payment, Management To Your Smartphone

21 Apr

Home ScreenThe mobile health market is growing like a weed these days. According to mHealthWatch and eHealth Initiative, there are 31,000 health and medical-related apps on the market today. In fact, over the last year, the number of health apps jumped 120 percent, and hundreds of apps now hit stores every month. Yet, in spite of this exponential growth, the mobile health space is still in its “Wild West” phase. In other words, it’s a work in progress.


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CBS News says some of its Twitter accounts were hacked

21 Apr

(Reuters) – Social media accounts maintained by CBS News programs, “60 Minutes” and “48 Hours,” were compromised on Saturday, the two programs’ official Twitter accounts said.

A post on the “60 Minutes” Twitter microblog account, @60Minutes, said, “PLEASE NOTE: Our Twitter account was compromised earlier today. We are working with Twitter to resolve.” Another post read, “A message that was posted earlier to this account was not written or sent by @60Minutes or its staff.”

The Twitter account for @48Hours showed a similar message, and several blogs said a third account, @CBSDenver, also had been hacked.

Tech bloggers posted screenshots of fake posts that appeared under the CBS accounts, including one from @48Hours that read, “General Dempsey calls for #Obama’s arrest under new anti-terror laws #48hours.”

On its own official account, @CBSNews, the news organization said it had “experienced problems” on the other two accounts, and added, “Twitter is resolving issues.”

The rogue posts appeared to have been removed from later on Saturday.

Copyright 2013 Thomson Reuters.

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Science surprise: Toxic protein made in unusual way may explain brain disorder

21 Apr

Friday, April 19, 2013

A bizarre twist on the usual way proteins are made may explain mysterious symptoms in the grandparents of some children with mental disabilities.

The discovery, made by a team of scientists at the University of Michigan Medical School, may lead to better treatments for older adults with a recently discovered genetic condition.

The condition, called Fragile X-associated Tremor Ataxia Syndrome (FXTAS), causes shakiness and balance problems and is often misdiagnosed as Parkinson’s disease. The grandchildren of people with the disease have a separate disorder called Fragile X syndrome, caused by problems in the same gene. The new discovery may also help shine light on that disease, though indirectly.

In a new paper published in the journal Neuron, the U-M-led team presents evidence that a toxic protein they’ve named FMRpolyG contributes to the death of nerve cells in FXTAS ? and that this protein is made in a very unusual way.

Normally, DNA is transcribed into RNA, and then a part of the RNA is translated into a protein that performs its function in cells. Where this translation process starts on the RNA is usually determined by a specific sequence called a start codon.

The gene mutation that causes FXTAS is a repeated DNA sequence that is made into RNA but normally is not made into protein because it lacks a start codon. However, the investigators discovered that when this repeat expands, it can trigger protein production by a new mechanism known as RAN translation.

Corresponding author Peter Todd, M.D., Ph.D., notes that this unusual translation process appears to stem from a long chain of repeated DNA “letters” found in the genes of both grandparents and kids with Fragile X mutations. Todd is the Bucky and Patti Harris Professor in the U-M Department of Neurology

“Essentially, we’ve found that a sequence of DNA which shouldn’t be made into protein is being made into protein ? and that this causes a toxicity in nerve cells,” he explains. “We believe that the protein forms aggregates, and that this is a major contributor to toxicity and symptoms in FXTAS.”

The U-M group went on to show how this RAN translation occurs in FXTAS and demonstrated that blocking it prevents the repeat mutation from being toxic, suggesting a new target for future treatments.

Fragile X tremor/ataxia syndrome or FXTAS was only discovered a decade ago. It may affect as many as one in every 3,000 men and one in 20,000 women, who have a repeat mutation in the gene known as FMR1. However, these patients don’t usually develop symptoms until late middle age, allowing them to pass the mutation on to their daughters, who can then have children where the DNA repeat that has grown much longer. In those children, especially in boys, it can cause severe intellectual disability and autism-like symptoms as the FMR1 gene shuts down and none of the normal protein is produced.

In fact, says Todd, it’s often only after a child is diagnosed with Fragile X syndrome through genetic testing that their grandfather or grandmother finds out that their own symptoms stem from FXTAS. Doctors in U-M’s Neurogenetics clinic for adults, and the Pediatric Genetics Clinic at U-M’s C.S. Mott Children’s Hospital, routinely work together to address the needs of Fragile X families.

“We have some treatments for the symptoms that FXTAS patients have, but we do not yet have a cure,” says Todd, who regularly sees patients with FXTAS and related disorders. “Better treatments are needed ? and this new discovery might help lead to novel strategies for clearing away or preventing the buildup of this toxic protein.”

In addition, he says, the discovery that Fragile X ataxia results in part from RAN translation could have significance both for other diseases like amyotrophic lateral sclerosis (ALS, also called Lou Gehrig’s disease) and certain forms of dementia that are caused by DNA repeats. It can also aid our understanding of basic biology. “This may represent a new way in which translational initiation events occur, and may have importance beyond this one disease,” he notes. Further research on how RAN translation occurs, and why, is needed.

The idea that proteins can be created without a “start site” flies in the face of what most students of biology have learned in the last century. “In biology, we’re finding that the rules we once thought were hard and fast have some wiggle room,” Todd says.


University of Michigan Health System:

Thanks to University of Michigan Health System for this article.

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Karisma Kapoor's Fitness Secrets | Tips on Food Fitness Life Love

1 Apr

Karisma Kapoor, the gorgeous actress who entertained us with her moves, enviable figure and a beautiful face is married and a mother of two today. She still maintains her drop dead gorgeous looks. How? Well, that no more a celebrity secret.

Karisma is highly inspired by Victoria Beckham. This helped her lose post-pregnancy fat in no time.
Today, Karisma has maintained a fit body and enviable looks just as Victoria Beckham. She eats really healthy. Her favourite cuisines include Japanese food, lots of fish, and chicken. The actress also believes in including a lot of raw vegetables and fruits in her diet.

Karisma believes in maintaining a healthy diet regime and does not starve herself. Today, she keeps a very slim physique. She does this by eating right, exercising occasionally, and running around after her two children.

Karisma Kapoor Diet Chart


? 2 pieces of whole wheat toast with some vegetables


? Mango/fruit salad


? Grilled Sandwich


? Dhokla




? Soup


? Chicken breast (no skin, no sauces) and roasted veggies

Karisma believes in eating healthy. She brings variety in her food by introducing vegetable curry and brown rice or steamed fish and chicken in her regular diet chart. The actress also includes 2-3 egg whites in the day to ensure adequate protein intake.

Karisma Kapoor?s Exercise Regimen

Karisma Kapoor has always maintained a fit body. She used to swim a lot during her school days. Today, she maintains the same regime by swimming with her kids during their holidays.

Karisma also likes to practise yoga. She takes long walks the natural way. Karisma prefers to walk in the building and even take the stairs whenever possible.

The actress is not a fan of gyms. In fact, her gym routines are just to maintain a toned body. She has appointed a personal trainer who would help her workout at least 3-4 times in a week.

Today, the actress keeps her children in her priority. However, she believes that her own health and fitness is equally important and works hard for it. She makes it a point to take care of her health, hair, and skin.

Karisma Kapoor?s Fitness Mantra

Eat healthy, workout and live healthy!

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Navy IDs SEAL killed in Ariz. parachuting accident

1 Apr

TUCSON, Ariz. (AP) ? Brett D. Shadle always had wanted to be a member of the Navy’s most elite special forces unit. A year after enlisting, he made it happen and went on to become a highly decorated member of the Navy’s famed SEAL Team 6.

U.S. military officials confirmed Saturday that Shadle, a 31-year-old special warfare operator chief, died Thursday when he and another SEAL collided in midair during a parachute training exercise over the rugged desert of southern Arizona.

Shadle was taken to University of Arizona Medical Center in Tucson, where he was pronounced dead. The other SEAL ? an unidentified E-6 petty officer first class ? remained in stable condition Saturday at the Tucson hospital.

Military officials said the accident was under investigation.

Family members said Shadle, of Elizabethville, Pa., was stationed in Virginia. He was married and had a 2-year-old son and 4-year-old daughter.

His uncle Donald Shadle, 67, of Elizabethville, expressed disbelief, saying his nephew had been on many overseas missions only to come back and get killed during a training exercise.

“He was always a good kid, and he always wanted to be a Navy SEAL and that’s what he did,” Donald Shadle said.

Shadle enlisted in the Navy in July 2000. The following year he completed his SEAL training and was assigned to his first unit in early 2002.

Navy officials said Shadle had earned multiple Bronze Star Medals with Valor and several service ribbons. While details about his deployments were secret, officials confirmed he had served in Afghanistan and Iraq.

Shadle and a fellow SEAL were practicing “routine military free-fall training” when the accident occurred Thursday afternoon, said U.S. Special Operations Command spokesman Kenneth McGraw. The SEALs collided in midair and landed in separate areas.

The command has a parachute testing and training facility at the Pinal Airpark northeast of Tucson, McGraw said. Training programs are operated there year-round.

The Navy‘s SEAL Team 6 gained international attention when it was revealed that members of the top secret unit had carried out a raid in Pakistan in 2011 in which Osama bin Laden was killed. Bin Laden became the most wanted man in the world after the Sept. 11, 2001, terrorist attacks that killed almost 3,000 people.

Team 6 was hit hard later that same year when 22 SEALs from the special unit were killed when the helicopter they were riding in was apparently hit by an insurgent’s rocket-propelled grenade. None of those killed on the helicopter was part of the bin Laden raid. Their deaths marked the nation’s single deadliest day of the decade-long war in Afghanistan.


Associated Press writers Susan Montoya Bryan in Albuquerque, N.M., and Ron Todt in Philadelphia contributed to this report.


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